Reaction: Activation of BAD by calcineurin
- in pathway: Activation of BAD and translocation to mitochondria
Calcineurin, the Ca2+ activated protein phosphatase, dephosphorylates BAD, promoting dissociation of BAD from 14-3-3 proteins and the translocation of BAD to the outer mitochondrial membrane (Wang et al. 1999).
Reaction - small molecule participants:
Pi [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-139906
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Reaction input - small molecules:
water
Reaction output - small molecules:
hydrogenphosphate
Reactome.org link: R-HSA-139906