Reaction: factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain
- in pathway: Common Pathway of Fibrin Clot Formation
Once the A chains of the Factor XIII tetramer have been cleaved by thrombin, the complex dissociates and the resulting A chain dimer binds Ca++ (one per peptide monomer) to form activated factor XIII (factor XIIIa).
Reaction - small molecule participants:
Ca2+ [extracellular region]
Reactome.org reaction link: R-HSA-140847
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Reaction input - small molecules:
calcium(2+)
Reaction output - small molecules:
Reactome.org link: R-HSA-140847