Reaction: PAO:FAD oxidises NASPM to PTCN
- in pathway: Interconversion of polyamines
Acetylated spermidine (NASPM) is oxidised by the flavoenzyme polyamine oxidase (PAOX, with FAD as cofactor) to produce putrescine (PTCN). PAOX is involved in the back-conversion of polyamines and thus the regulation of their intracellular concentrations (Vujcic et al. 2003).
Reaction - small molecule participants:
3AAPNAL [peroxisomal matrix]
H2O2 [peroxisomal matrix]
PTCN [peroxisomal matrix]
O2 [peroxisomal matrix]
H2O [peroxisomal matrix]
NASPM [peroxisomal matrix]
3AAPNAL [peroxisomal matrix]
H2O2 [peroxisomal matrix]
PTCN [peroxisomal matrix]
O2 [peroxisomal matrix]
H2O [peroxisomal matrix]
NASPM [peroxisomal matrix]
Reactome.org reaction link: R-HSA-141348
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Reaction input - small molecules:
dioxygen
water
N(1)-acetylspermidine
dioxygen
water
N(1)-acetylspermidine
Reaction output - small molecules:
3-acetamidopropanal
hydrogen peroxide
1,4-butanediammonium
3-acetamidopropanal
hydrogen peroxide
1,4-butanediammonium
Reactome.org link: R-HSA-141348