Reaction: PAOX:FAD oxidises NASPN to SPM
- in pathway: Interconversion of polyamines
Acetylated spermine (NASPN) is oxidised by the flavoenzyme polyamine oxidase (PAOX, woth FAD as cofactor) to produce spermidine (SPM). PAOX is involved in the back-conversion of polyamines and thus the regulation of their intracellular concentrations (Vujcic et al. 2003).
Reaction - small molecule participants:
SPM [peroxisomal matrix]
3AAPNAL [peroxisomal matrix]
H2O2 [peroxisomal matrix]
O2 [peroxisomal matrix]
H2O [peroxisomal matrix]
NASPN [peroxisomal matrix]
SPM [peroxisomal matrix]
3AAPNAL [peroxisomal matrix]
H2O2 [peroxisomal matrix]
O2 [peroxisomal matrix]
H2O [peroxisomal matrix]
NASPN [peroxisomal matrix]
Reactome.org reaction link: R-HSA-141351
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Reaction input - small molecules:
dioxygen
water
N(1)-acetylsperminium(3+)
dioxygen
water
N(1)-acetylsperminium(3+)
Reaction output - small molecules:
spermidine(3+)
3-acetamidopropanal
hydrogen peroxide
spermidine(3+)
3-acetamidopropanal
hydrogen peroxide
Reactome.org link: R-HSA-141351