Reaction: The ABCC family mediates organic anion transport
- in pathway: ABC-family proteins mediated transport
The multidrug resistance associated protein (MRPs) subfamily of the ABC transporter family can transport a wide and diverse range of organic anions that can be endogenous compounds and xenobiotics and their metabolites. All human MRPs (except MRP9) can mediate these transport reactions (Deeley et al. 2006). Separately, specific reactions have also been annotated to describe the roles of ABCC4 in platelet dense granule assembly, of ABCC1 in LTC4 export (an aspect of leukotriene synthesis), and of ABCC3 in bile salt efflux.
Reaction - small molecule participants:
Pi [cytosol]
ADP [cytosol]
organic anion [extracellular region]
H2O [cytosol]
ATP [cytosol]
organic anion [cytosol]
Reactome.org reaction link: R-HSA-1454916
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Reaction input - small molecules:
water
ATP(4-)
organic anion
Reaction output - small molecules:
hydrogenphosphate
ADP(3-)
organic anion
Reactome.org link: R-HSA-1454916