Reaction: Binding of defensins to lipid II
- in pathway: Defensins
In S. aureus, rather than cause gross membrane changes, HNP-1 (de Leeuw et al. 2010) and hBD3 (Sass et al. 2011) appear to interfere with cell wall biosynthetic pathways by binding to Lipid II (undecaprenylpyrophosphate-MurNAc[pentapeptide]-GlcNAc), an essential precursor of bacterial cell walls and the target of several antibiotics (Breukink & de Krujiff 2007). The transformation of monomeric lipid II into a polymeric peptidoglycan by the bifunctional S. aureus enzyme Penicillin-binding protein 2 (PBP2) is inhibited by hBD3 (Sass et al. 2011) resulting in local lesions of the cell wall layer through which membranes and cytoplasmic contents ultimately protrude.
Reaction - small molecule participants:
Lipid II [plasma membrane]
Reactome.org reaction link: R-HSA-1467209
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Reaction input - small molecules:
lipid II
Reaction output - small molecules:
Reactome.org link: R-HSA-1467209