Reaction: DHNTP is dephosphorylated by PTPS to PTHP
6-pyruvoyl tetrahydrobiopterin synthase (PTPS) (Takikawa et al. 1986) catalyses the second step in BH4 biosynthesis, the dephosphorylation of DHNTP to 6-pyruvoyl-tetrahydropterin (PTHP). PTPS is believed to function as a homohexamer (Nar et al. 1994, Bürgisser et al. 1994) and has a requirement for Zn2+ (one Zn2+ ion bound per subunit) and Mg2+ ions for activity (Bürgisser et al. 1995). The phosphorylation of Ser-19 is an essential modification for enzyme activity (Scherer-Oppliger et al. 1999).
Reaction - small molecule participants:
PPP [cytosol]
PTHP [cytosol]
DHNTP [cytosol]
Reactome.org reaction link: R-HSA-1474184
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Reaction input - small molecules:
7,8-dihydroneopterin 3'-triphosphate(4-)
Reaction output - small molecules:
triphosphate ion
dyspropterin
Reactome.org link: R-HSA-1474184