Reaction: PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)
- in pathway: Synthesis of PA
At the outer mitochondrial (OM) membrane, phosphatidic acid (PA) is hydrolyzed, and has one of its acyl chains cleaved off, by phospholipase A2 alpha/beta/delta/zeta (PLA2G4A/B/D/F) to form 1-acyl lysophosphatidic acid (LPA) (Ghomashchi et al. 2010).
Reaction - small molecule participants:
1-acyl LPA [mitochondrial outer membrane]
LCFA(-) [mitochondrial outer membrane]
H2O [cytosol]
PA [mitochondrial outer membrane]
Reactome.org reaction link: R-HSA-1482604
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Reaction input - small molecules:
water
phosphatidate(2-)
Reaction output - small molecules:
1-acyl-sn-glycerol 3-phosphate
long-chain fatty acid anion
Reactome.org link: R-HSA-1482604