Reaction: 2-acyl LPC is hydrolyzed to GPCho by PLA2[8]
- in pathway: Hydrolysis of LPC
At the endoplasmic reticulum (ER) membrane, 2-acyl lysophosphatidylcholine (LPC) is hydrolyzed to glycerophosphocholine (GPCho) by cytosolic phospholipase A2 alpha/beta/delta/epsilon/zeta (PLA2G4A/B/D/E/F) (Yamashita et al. 2005, Ghomashchi et al. 2010, Yamashita et al. 2009, Sharp et al. 1994) or by Phospholipase B1-like (PLBD1) (Xu et al. 2009). PLBD1 also acts as a phospholipase A2 but in addition has the propensity to hydrolyze the lysophospholipid formed in its initial reaction.
Reaction - small molecule participants:
GPCho [cytosol]
LCFA(-) [endoplasmic reticulum membrane]
H2O [cytosol]
2-acyl LPC [endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-1482612
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Reaction input - small molecules:
water
2-acyl-sn-glycero-3-phosphocholine(1+)
Reaction output - small molecules:
choline alfoscerate
long-chain fatty acid anion
Reactome.org link: R-HSA-1482612