Reaction: 2-acyl LPG is acylated to PG by LPGAT
- in pathway: Acyl chain remodelling of PG
At the endoplasmic reticulum (ER) membrane, lysophospholipid acyltransferases acylate 2-acyl lysophosphatidylglycerol (LPG) to form phosphatidylglycerol (PG). The lysophospholipid acyltransferases involved are: lysophosphatidylcholine acyltransferase 1 (LPCAT1) (Nakanishi et al. 2006, Chen et al. 2006), lysophospholipid acyltransferase LPCAT4 (LPCAT4) aka LPEAT2 (Cao et al. 2008, Ye et al. 2005); or acyl-CoA:lysophosphatidylglycerol acyltransferase (LPGAT1) (Yang et al. 2004).
Reaction - small molecule participants:
PG [endoplasmic reticulum membrane]
CoA-SH [cytosol]
2-acyl LPG [endoplasmic reticulum membrane]
acyl-CoA [cytosol]
Reactome.org reaction link: R-HSA-1482635
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Reaction input - small molecules:
2-acyl-sn-glycero-3-phosphoglycerol
acyl-CoA
Reaction output - small molecules:
1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-)
coenzyme A(4-)
Reactome.org link: R-HSA-1482635