Reaction: 1-acyl LPS is acylated to PS by LPSAT
- in pathway: Acyl chain remodelling of PS
At the endoplasmic reticulum (ER) membrane, lysophospholipid acyltransferases acylate 1-acyl lysophosphatidylserine (LPS) to form phosphatidylserine (PS). The lysophospholipid acyltransferases involved are: lysophospholipid acyltransferase 5 (LPCAT3) (Gijon et al. 2008, Hishikawa et al. 2008); lysophospholipid acyltransferase LPCAT4 (LPCAT4) aka LPEAT2 (Cao et al. 2008); or lysophospholipid acyltransferase 1 (MBOAT1) aka LPEAT1 (Hishikawa et al. 2008, Gijon et al. 2008).
Reaction - small molecule participants:
CoA-SH [cytosol]
PS [endoplasmic reticulum membrane]
acyl-CoA [cytosol]
1-acyl LPS [endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-1482636
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Reaction input - small molecules:
acyl-CoA
1-acyl-sn-glycero-3-phosphoserine
Reaction output - small molecules:
coenzyme A(4-)
3-sn-phosphatidyl-L-serine
Reactome.org link: R-HSA-1482636