Reaction: 2-acyl LPE is acylated to PE by LPEAT
- in pathway: Acyl chain remodelling of PE
At the endoplasmic reticulum (ER) membrane, lysophospholipid acyltransferases acylate 2-acyl lysophosphatidylethanolamine (LPE) to form phosphatidylethanolamine (PE). The lysophospholipid acyltransferases involved are: lysophospholipid acyltransferase 1 (MBOAT1) aka LPEAT1 (Gijon et al. 2008, Hishikawa et al. 2008); lysophospholipid acyltransferase LPCAT4 (LPCAT4) aka LPEAT2 (Cao et al. 2008, Ye et al. 2005); lysophospholipid acyltransferase 2 (MBOAT2) aka LPCAT4 (Hishikawa et al. 2008, Gijon et al. 2008); lysophospholipid acyltransferase 5 (LPCAT3) (Hishikawa et al. 2008, Zhao et al. 2008, Gijon et al. 2008, Jain et al. 2009, Kazachkov et al. 2008).
Reaction - small molecule participants:
CoA-SH [cytosol]
PE [endoplasmic reticulum membrane]
2-acyl LPE [endoplasmic reticulum membrane]
acyl-CoA [cytosol]
Reactome.org reaction link: R-HSA-1482646
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Reaction input - small molecules:
2-acyl-sn-glycero-3-phosphoethanolamine
acyl-CoA
Reaction output - small molecules:
coenzyme A(4-)
phosphatidylethanolamine zwitterion
Reactome.org link: R-HSA-1482646