Reaction: PA is hydrolysed to 1-acyl LPA by PLA2G2A
- in pathway: Synthesis of PA
At the endoplasmic reticulum (ER) membrane, phosphatidic acid (PA) is hydrolyzed, and has one of its acyl chains cleaved off, by membrane-associated phospholipase A2 gamma 2A (PLA2G2A), to form 1-acyl lysophosphatidic acid (LPA) (Singer et al. 2002).
Reaction - small molecule participants:
1-acyl LPA [cytosol]
LCFA(-) [endoplasmic reticulum membrane]
H2O [cytosol]
PA [endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-1482679
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Reaction input - small molecules:
water
phosphatidate(2-)
Reaction output - small molecules:
1-acyl-sn-glycerol 3-phosphate
long-chain fatty acid anion
Reactome.org link: R-HSA-1482679