Reaction: PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)
- in pathway: Acyl chain remodelling of PG
At the inner mitochondrial membrane (IM), phosphatidylglycerol (PG) is hydrolyzed, and has one of its acyl chains cleaved off, by phospholipase A2 beta (PLA2G4B) to form 1-acyl lysophosphatidylglycerol (LPG) (Ghomashchi et al. 2010, Singer et al. 2002).
Reaction - small molecule participants:
1-acyl LPG [mitochondrial inner membrane]
LCFA(-) [mitochondrial inner membrane]
PG [mitochondrial inner membrane]
H2O [mitochondrial matrix]
Reactome.org reaction link: R-HSA-1482745
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Reaction input - small molecules:
1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-)
water
Reaction output - small molecules:
1-acyl-sn-glycero-3-phosphoglycerol
long-chain fatty acid anion
Reactome.org link: R-HSA-1482745