Reaction: PS is hydrolyzed to 1-acyl LPS by PLA2[9]
- in pathway: Acyl chain remodelling of PS
At the endoplasmic reticulum (ER) membrane, phosphatidylserine (PS) is hydrolyzed, and has one of its acyl chains cleaved off, by cytosolic phospholipase A2 alpha/beta/delta/epsilon/zeta (PLA2G4A,B,D/E/F) (Ghomashchi et al. 2010), or by group XVI phospholipase A2 (PLA2G16) (Duncan et al. 2008). This produces 1-acyl lysophosphatidylserine (LPS).
Reaction - small molecule participants:
LCFA(-) [endoplasmic reticulum membrane]
1-acyl LPS [endoplasmic reticulum membrane]
H2O [cytosol]
PS [endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-1482771
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Reaction input - small molecules:
water
3-sn-phosphatidyl-L-serine
Reaction output - small molecules:
long-chain fatty acid anion
1-acyl-sn-glycero-3-phosphoserine
Reactome.org link: R-HSA-1482771