Reaction: MLCL is acylated to CL by HADH (IM)
- in pathway: Acyl chain remodeling of CL
At the inner mitochondrial membrane (IM), the trifunctional enzyme HADH (3-hydroxyacyl-CoA dehydrogenase), an octamer of four alpha (HADHA) and four beta (HADHB) subunits, acylates monolysocardiolipin (MLCL) to cardiolipin (CL) (Taylor & Hatch 2009).
Reaction - small molecule participants:
cardiolipin [mitochondrial inner membrane]
CoA-SH [mitochondrial matrix]
MLCL [mitochondrial inner membrane]
acyl-CoA [mitochondrial matrix]
Reactome.org reaction link: R-HSA-1482775
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Reaction input - small molecules:
2-monolysocardiolipin
acyl-CoA
Reaction output - small molecules:
cardiolipin
coenzyme A(4-)
Reactome.org link: R-HSA-1482775