Reaction: TAG is hydrolyzed to DAG by PNPLA2/3
- in pathway: Acyl chain remodeling of DAG and TAG
At the endoplasmic reticulum (ER) membrane, triacylglycerol (TAG) is hydrolyzed, removing one of its acyl groups to form diacylglycerol (DAG) by patatin-like phospholipase domain-containing protein 2/3 (PNPLA2/3) (He et al. 2010, Jenkins et al. 2004, Basantani et al. 2011).
Reaction - small molecule participants:
LCFA(-) [endoplasmic reticulum membrane]
DAG [endoplasmic reticulum membrane]
H2O [cytosol]
TAG [endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-1482777
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Reaction input - small molecules:
water
triglyceride
Reaction output - small molecules:
long-chain fatty acid anion
1,2-diacyl-sn-glycerol
Reactome.org link: R-HSA-1482777