Reaction: CL is hydrolyzed to MLCL by PLA2G6 (IM)
- in pathway: Acyl chain remodeling of CL
At the inner mitochondrial membrane (IM), calcium-independent phospholipase A2 gamma (PLA2G6) hydrolyzes, removing one of the acyl chains, cardiolipin (CL) to form monolysocardiolipin (MLCL). This reaction is inferred from rats. PLA2G6 has also been characterized in humans (Larsson et al. 1998, Ma et al. 1999, Larsson Forsell et al. 1999).
Reaction - small molecule participants:
MLCL [mitochondrial inner membrane]
LCFA(-) [mitochondrial inner membrane]
cardiolipin [mitochondrial inner membrane]
H2O [mitochondrial matrix]
Reactome.org reaction link: R-HSA-1482778
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Reaction input - small molecules:
cardiolipin
water
Reaction output - small molecules:
2-monolysocardiolipin
long-chain fatty acid anion
Reactome.org link: R-HSA-1482778