Reaction: MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)
- in pathway: Acyl chain remodeling of CL
At the inner mitochondrial membrane (IM), tafazzin (TAZ) converts monolysocardiolipin (MLCL) and phosphatidylcholine (PC) to cardiolipin (CL) and 1-acyl lysophosphatidylcholine (LPC) (Xu et al. 2003, Xu et al. 2006, Malhotra et al. 2009). Although this reaction is reversible, the net effect of the phospholipase A and acyltransferase reactions drives it towards the formation of LPC and CL.
Reaction - small molecule participants:
cardiolipin [mitochondrial inner membrane]
1-acyl LPC [mitochondrial inner membrane]
PC [mitochondrial inner membrane]
MLCL [mitochondrial inner membrane]
Reactome.org reaction link: R-HSA-1482781
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Reaction input - small molecules:
1,2-diacyl-sn-glycero-3-phosphocholine
2-monolysocardiolipin
Reaction output - small molecules:
cardiolipin
1-O-acyl-sn-glycero-3-phosphocholine(1+)
Reactome.org link: R-HSA-1482781