Reaction: PI is hydrolyzed to 1-acyl LPI by PLA2[11]
- in pathway: Acyl chain remodelling of PI
At the endoplasmic reticulum (ER) membrane, phosphatidylinositol (PI) is hydrolyzed, and has one of its acyl chains cleaved off, by a phospholipase A2 to form 1-acyl lysophosphatidylinositol (LPI). The phospholipases are either cytosolic phospholipase A2 alpha/beta/zeta (PLA2G4A/D/F) (Ghomashchi et al. 2010), group XVI phospholipase A2 (PLA2G16) (Duncan et al. 2008), or Phospholipase B-like 1 (PLBD1) (Xu et al. 2009). PLBD1 also acts as a phospholipase A2 but in addition has the propensity to hydrolyze the lysophospholipid formed in its initial reaction.
Reaction - small molecule participants:
1-acyl LPI [endoplasmic reticulum membrane]
LCFA(-) [endoplasmic reticulum membrane]
H2O [cytosol]
PI [endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-1482825
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Reaction input - small molecules:
water
1-phosphatidyl-1D-myo-inositol(1-)
Reaction output - small molecules:
1-acyl-sn-glycero-3-phospho-D-myo-inositol
long-chain fatty acid anion
Reactome.org link: R-HSA-1482825