Reaction: PE is hydrolyzed to 2-acyl LPE by PLA2[4]
- in pathway: Acyl chain remodelling of PE
At the endoplasmic reticulum (ER) membrane, phosphatidylethanolamine (PE) is hydrolyzed, and has one of its acyl chains cleaved off by cytosolic phospholipase A2 alpha/delta/epsilon/zeta (PLA2G4A/D/E/F) (Ghomashchi et al. 2010). This produces 2-acyl lysophosphatidylethanolamine (LPE). Cytosolic phospholipase A2 enzymes show not only PLA2 hydrolyzing activity to form the 1-acyl lysophospholipid but also have a degree of PLA1 activity, producing a 2-acyl lysophospholipid.
Reaction - small molecule participants:
2-acyl LPE [endoplasmic reticulum membrane]
LCFA(-) [endoplasmic reticulum membrane]
H2O [cytosol]
PE [endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-1482828
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Reaction input - small molecules:
water
phosphatidylethanolamine zwitterion
Reaction output - small molecules:
2-acyl-sn-glycero-3-phosphoethanolamine
long-chain fatty acid anion
Reactome.org link: R-HSA-1482828