Reaction: PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM)
- in pathway: Acyl chain remodelling of PG
At the inner mitochondrial (IR) membrane, phosphatidylglycerol (PG) is hydrolysed, and has one of its acyl chains cleaved off, by phospholipase A2 beta (PLA2G4B) (Ghomashchi et al. 2010) to form 2-acyl lysophosphatidylglycerol (LPG). Phospholipase A2 enzymes show not only PLA2 hydrolysing activity to form the 1-acyl lysophospholipid but also have a degree of PLA1 activity, producing a 2-acyl lysophospholipid.
Reaction - small molecule participants:
2-acyl LPG [mitochondrial inner membrane]
LCFA(-) [mitochondrial inner membrane]
PG [mitochondrial inner membrane]
H2O [mitochondrial matrix]
Reactome.org reaction link: R-HSA-1482847
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Reaction input - small molecules:
1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-)
water
Reaction output - small molecules:
2-acyl-sn-glycero-3-phosphoglycerol
long-chain fatty acid anion
Reactome.org link: R-HSA-1482847