Reaction: PC is hydrolysed to 2-acyl LPC by PLA2[7]
- in pathway: Acyl chain remodelling of PC
At the endoplasmic reticulum (ER) membrane, phosphatidylcholine (PC) is hydrolysed, and has one of its acyl chains cleaved off, by cytosolic phospholipase A2 alpha/beta/delta/epsilon/zeta (PLA2G4A/B/D/E/F) (Ghomashchi et al. 2010). This produces 2-acyl lysophosphatidylcholine (LPC). Cytosolic phospholipase A2 enzymes show not only PLA2 hydrolysing activity to form the 1-acyl lysophospholipid but also have a degree of PLA1 activity, producing a 2-acyl lysophospholipid.
Reaction - small molecule participants:
LCFA(-) [endoplasmic reticulum membrane]
2-acyl LPC [endoplasmic reticulum membrane]
H2O [cytosol]
PC [endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-1482862
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Reaction input - small molecules:
water
1,2-diacyl-sn-glycero-3-phosphocholine
Reaction output - small molecules:
long-chain fatty acid anion
2-acyl-sn-glycero-3-phosphocholine(1+)
Reactome.org link: R-HSA-1482862