Reaction: PE is hydrolyzed to 1-acyl LPE by PLA2[3]
- in pathway: Acyl chain remodelling of PE
At the endoplasmic reticulum (ER) membrane, phosphatidylethanolamine (PE) is hydrolyzed, and has one of its acyl chains cleaved off, by membrane-associated phospholipase A2 gamma 2A, (PLA2G2A) or by calcium-independent phospholipase A2-gamma (PNPLA8), to form 1-acyl lysophosphatidylethanolamine (LPE) (Murakami et al. 2005, Kramer et al. 1989, Singer et al. 2002).
Reaction - small molecule participants:
1-acyl LPE [endoplasmic reticulum membrane]
LCFA(-) [endoplasmic reticulum membrane]
H2O [cytosol]
PE [endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-1482887
======
Reaction input - small molecules:
water
phosphatidylethanolamine zwitterion
Reaction output - small molecules:
1-acyl-sn-glycero-3-phosphoethanolamine
long-chain fatty acid anion
Reactome.org link: R-HSA-1482887