Reaction: DAG is acylated to TAG by DGAT1/2
- in pathway: Acyl chain remodeling of DAG and TAG
At the endoplasmic reticulum (ER) membrane, diacylglycerol (DAG) is acylated and forms triacylglycerol (TAG) by the action of diacylglycerol O-acyltransferase 1 (DGAT1) tetramer or by diacylglycerol O-acyltransferase 2 (DGAT2) (Wakimoto et al. 2003, Oelkers et al. 1998, Cases et al. 2001).
Reaction - small molecule participants:
TAG [endoplasmic reticulum membrane]
CoA-SH [cytosol]
acyl-CoA [cytosol]
DAG [endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-1482889
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Reaction input - small molecules:
acyl-CoA
1,2-diacyl-sn-glycerol
Reaction output - small molecules:
triglyceride
coenzyme A(4-)
Reactome.org link: R-HSA-1482889