Reaction: PS is hydrolyzed to 2-acyl LPS by PLA2[10]
- in pathway: Acyl chain remodelling of PS
At the endoplasmic reticulum (ER) membrane, phosphatidylserine (PS) is hydrolyzed, and has one of its acyl chains cleaved off, by cytosolic phospholipase A2 alpha/delta/zeta (PLA2G4A/D/F) (Ghomashchi et al. 2010). This produces 2-acyl lysophosphatidylserine (LPS). Cytosolic phospholipase A2 enzymes show not only PLA2 hydrolyzing activity to form the 1-acyl lysophospholipid but also have a degree of PLA1 activity, producing a 2-acyl lysophospholipid.
Reaction - small molecule participants:
2-acyl LPS [endoplasmic reticulum membrane]
LCFA(-) [endoplasmic reticulum membrane]
H2O [cytosol]
PS [endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-1482897
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Reaction input - small molecules:
water
3-sn-phosphatidyl-L-serine
Reaction output - small molecules:
2-acyl-sn-glycero-3-phosphoserine
long-chain fatty acid anion
Reactome.org link: R-HSA-1482897