Reaction: PG is hydrolyzed to 1-acyl LPG by PLA2[1]
- in pathway: Acyl chain remodelling of PG
At the endoplasmic reticulum (ER) membrane, phosphatidylglycerol (PG) is hydrolyzed, and has one of its acyl chains cleaved off, by cytosolic phospholipase A2 alpha/beta/delta/zeta (PLA2G4A/B/D/F) (Ghomashchi et al. 2010) to form 1-acyl lysophosphatidylglycerol (LPG).
Reaction - small molecule participants:
LCFA(-) [endoplasmic reticulum membrane]
1-acyl LPG [endoplasmic reticulum membrane]
PG [endoplasmic reticulum membrane]
H2O [cytosol]
Reactome.org reaction link: R-HSA-1482900
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Reaction input - small molecules:
1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-)
water
Reaction output - small molecules:
long-chain fatty acid anion
1-acyl-sn-glycero-3-phosphoglycerol
Reactome.org link: R-HSA-1482900