Reaction: PI is hydrolyzed to 2-acyl LPI by PLA2[13]
- in pathway: Acyl chain remodelling of PI
At the endoplasmic reticulum (ER) membrane, phosphatidylinositol (PI) is hydrolyzed, and has one of its acyl chains cleaved off, by cytosolic phospholipase A2 delta/epsilon (PLA2G4D/E) Ghomashchi et al. 2010). This produces 2-acyl lysophosphatidylinositol (LPI). Cytosolic phospholipase A2 enzymes show not only PLA2 hydrolyzing activity to form the 1-acyl lysophospholipid but also have a degree of PLA1 activity, producing a 2-acyl lysophospholipid.
Reaction - small molecule participants:
2-acyl LPI [endoplasmic reticulum membrane]
LCFA(-) [endoplasmic reticulum membrane]
H2O [cytosol]
PI [endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-1482932
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Reaction input - small molecules:
water
1-phosphatidyl-1D-myo-inositol(1-)
Reaction output - small molecules:
2-acyl-sn-glycero-3-phospho-D-myo-inositol
long-chain fatty acid anion
Reactome.org link: R-HSA-1482932