Reaction: PG and CDP-DAG are converted to CL by CRLS1
- in pathway: Synthesis of CL
At the inner mitochondrial membrane (IM), cardiolipin synthase (CRLS1) converts phosphatidylglycerol (PG) and cytidine diphosphate-diacylglycerol (CDP-DAG) into cardiolipin (CL) (Lu et al. 2006, Houtkooper et al. 2006).
Reaction - small molecule participants:
cardiolipin [mitochondrial inner membrane]
CMP [mitochondrial matrix]
PG [mitochondrial inner membrane]
CDP-DAG [mitochondrial inner membrane]
Reactome.org reaction link: R-HSA-1483063
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Reaction input - small molecules:
1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-)
CDP-diacylglycerol(2-)
Reaction output - small molecules:
cardiolipin
cytidine 5'-monophosphate(2-)
Reactome.org link: R-HSA-1483063