Reaction: PCho and CTP are condensed to CDP-Cho by PCYT1 dimer
- in pathway: Synthesis of PC
At the endoplasmic reticulum (ER) membrane, active membrane-bound choline-phosphate cytidylyltransferase A (PCYT1A) or B (PCYT1B) homodimer condenses phosphocholine (PCho) and cytidine triphosphate (CTP) to produce CDP-choline (CDP-Cho) (Lykidis et al. 1998).
Reaction - small molecule participants:
PPi [cytosol]
CDP-Cho [cytosol]
CTP [cytosol]
PCho [cytosol]
Reactome.org reaction link: R-HSA-1483081
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Reaction input - small molecules:
CTP(4-)
phosphocholines
Reaction output - small molecules:
diphosphate(3-)
CDP-choline
Reactome.org link: R-HSA-1483081