Reaction: PA is converted to CDP-DAG by CDS1
- in pathway: Synthesis of PI
At the endoplasmic reticulum (ER) membrane, phosphatidate cytidylyltransferase 1 (CDS1) converts phosphatidic acid (PA) and cytidine triphosphate (CTP) into cytidine diphosphate-diacylglycerol (CDP-DAG). Both ER and mitochondrial membranes have the capability to synthesize cytidine diphosphate-diacylglycerol (CDP-DAG) with phosphatidate cytidylyltransferase 1 and 2 (CDS1 and CDS2) (Lykidis et al. 1997). However, transport of CDP-DAG between organelles cannot be ruled out (Stuhne-Sekalec et al. 1986).
Reaction - small molecule participants:
PPi [cytosol]
CDP-DAG [endoplasmic reticulum membrane]
CTP [cytosol]
PA [endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-1483121
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Reaction input - small molecules:
CTP(4-)
phosphatidate(2-)
Reaction output - small molecules:
diphosphate(3-)
CDP-diacylglycerol(2-)
Reactome.org link: R-HSA-1483121