Reaction: PC is transphosphatidylated to PG by PLD1-4/6
- in pathway: Synthesis of PG
In the endoplasmic reticulum (ER) membrane, phospholipase D1-4,6 (PLD1-4,6) transphosphatidylates phosphatidylcholine (PC) with glycerol to displace choline (Cho) and form phosphatidylglycerol (PG). This reaction is inferred from rats, but PLD enzymes are present in humans (Hammond et al. 1995, Steed et al. 1998, Cao et al. 1997).
Reaction - small molecule participants:
Cho [cytosol]
PG [endoplasmic reticulum membrane]
PC [endoplasmic reticulum membrane]
Glycerol [cytosol]
Reactome.org reaction link: R-HSA-1483142
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Reaction input - small molecules:
1,2-diacyl-sn-glycero-3-phosphocholine
glycerol
Reaction output - small molecules:
choline
1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-)
Reactome.org link: R-HSA-1483142