Reaction: PA is converted to CDP-DAG by CDS2
- in pathway: Synthesis of PG
At the inner mitochondrial (IM) membrane, phosphatidate cytidylyltransferase 2 (CDS2) converts phosphatidic acid (PA) and cytidine triphosphate (CTP) into cytidine diphosphate-diacylglycerol (CDP-DAG). Both ER and mitochondrial membranes have the capability to synthesise cytidine diphosphate-diacylglycerol (CDP-DAG) with phosphatidate cytidylyltransferase 1 and 2 (CDS1 and CDS2) (Lykidis et al. 1997, Schlame & Haldar 1993). However, transport of CDP-DAG between organelles cannot be ruled out (Stuhne-Sekalec et al. 1986).
Reaction - small molecule participants:
PPi [mitochondrial matrix]
CDP-DAG [mitochondrial inner membrane]
PA [mitochondrial inner membrane]
CTP [mitochondrial matrix]
Reactome.org reaction link: R-HSA-1483165
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Reaction input - small molecules:
phosphatidate(2-)
CTP(4-)
Reaction output - small molecules:
diphosphate(3-)
CDP-diacylglycerol(2-)
Reactome.org link: R-HSA-1483165