Reaction: PC is hydrolyzed to PA and choline by PLD1/2
- in pathway: Synthesis of PA
Phosphatidylcholine (PC) is hydrolyzed to phosphatidic acid (PA) and choline (Cho) by the enzymes phospholipase D1/2 (PLD1/2), at the endoplasmic reticulum (ER) membrane (Lopez et al. 1998, Hammond et al. 1995).
Reaction - small molecule participants:
Cho [cytosol]
PA [endoplasmic reticulum membrane]
H2O [cytosol]
PC [endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-1483182
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Reaction input - small molecules:
water
1,2-diacyl-sn-glycero-3-phosphocholine
Reaction output - small molecules:
choline
phosphatidate(2-)
Reactome.org link: R-HSA-1483182