Reaction: PC is converted to PS by PTDSS1
- in pathway: Synthesis of PS
At the endoplasmic reticulum (ER) membrane, phosphatidylserine synthase 1 (PTDSS1) converts phosphatidylcholine (PC) into phosphatidylserine (PS) by facilitating the exchange of L-Serine (L-Ser) with the choline (Cho) head group (Saito et al. 1998, Tomohiro et al. 2009).
Reaction - small molecule participants:
Cho [cytosol]
PS [endoplasmic reticulum membrane]
PC [endoplasmic reticulum membrane]
L-Ser [cytosol]
Reactome.org reaction link: R-HSA-1483186
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Reaction input - small molecules:
1,2-diacyl-sn-glycero-3-phosphocholine
L-serine zwitterion
Reaction output - small molecules:
choline
3-sn-phosphatidyl-L-serine
Reactome.org link: R-HSA-1483186