Reaction: PG is converted to BMP
- in pathway: Synthesis of BMP
The biosynthetic pathway of lysobisphosphatidic acid, also known as bis(monoacylglycerol) hydrogen phosphate (BMP), is still not fully understood with the in vivo enzymes responsible yet to be fully identified. It appears to involve multiple steps including hydrolysis of phosphatidylglycerol (PG) by a phospholipase A2, acylation, and a reorientation of the phosphoryl ester (Poorthuis & Hostetler 1978, Heravi & Waite 1999, Hullin-Matsuda et al. 2007, Gallala & Sandhoff 2010).
Reaction - small molecule participants:
BMP [late endosome membrane]
PG [late endosome membrane]
Reactome.org reaction link: R-HSA-1483209
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Reaction input - small molecules:
1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-)
Reaction output - small molecules:
lysobisphosphatidic acid
Reactome.org link: R-HSA-1483209