Reaction: PS is decarboxylated to PE by PISD
- in pathway: Synthesis of PE
At the inner mitochondrial (IM) membrane, phosphatidylserine decarboxylase proenzyme (heterodimer of two chains from the same protein) (PISD) decarboxylates phosphatidylserine (PS) to phosphatidylethanolamine (PE). This event has been inferred from rats and limited data for a human PISD (Forbes et al. 2007).
Reaction - small molecule participants:
PE [mitochondrial inner membrane]
CO2 [mitochondrial matrix]
PS [mitochondrial inner membrane]
Reactome.org reaction link: R-HSA-1483212
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Reaction input - small molecules:
3-sn-phosphatidyl-L-serine
Reaction output - small molecules:
phosphatidylethanolamine zwitterion
carbon dioxide
Reactome.org link: R-HSA-1483212