Reaction: Superoxide reacts rapidly with NO to form peroxynitrite (ONOO-)
- in pathway: eNOS activation
Superoxide (O2.-) formed from an uncoupled eNOS action, together with nitric oxide (NO) formed from a coupled eNOS action, readily react together to fom peroxynitrite (ONOO-) (Jourd'heuil et al. 2001, Reiter et al. 2000).
Reaction - small molecule participants:
Peroxynitrite [cytosol]
NO [cytosol]
O2.- [cytosol]
Reactome.org reaction link: R-HSA-1497878
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Reaction input - small molecules:
nitric oxide
superoxide
Reaction output - small molecules:
peroxynitrite
Reactome.org link: R-HSA-1497878