Reaction: factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst)
- in pathway: Intrinsic Pathway of Fibrin Clot Formation
Factor IXa, in a complex with factor VIIIa on the surfaces of activated platelets (the "intrinsic tenase complex"), catalyzes the formation of activated factor X with high efficiency. The amino terminal part of the heavy chain of factor X, the factor X activation peptide, is released. (This peptide has no known function.)
Reaction - small molecule participants:
Ca2+ [extracellular region]
Reactome.org reaction link: R-HSA-158164
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Reaction input - small molecules:
calcium(2+)
Reaction output - small molecules:
Reactome.org link: R-HSA-158164