Reaction: SULT1A1 dimer sulfonates PARA to PARA-SO4
- in pathway: Cytosolic sulfonation of small molecules
Cytosolic sulfotransferase 1A1 (SULT1A1), in dimeric form, can sulfonate the widely used analgesic and antipyretic drug paracetamol (PARA aka acetaminophen). Around 20-30% of PARA is metabolised via sulfonation by the liver (Parkinson 1995, Yamazoe et al. 1995, Strott 2002).
Reaction - small molecule participants:
PARA-SO4 [cytosol]
PAP [cytosol]
PAPS [cytosol]
Reactome.org reaction link: R-HSA-158468
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Reaction input - small molecules:
3'-phosphonato-5'-adenylyl sulfate(4-)
Reaction output - small molecules:
paracetamol sulfate
adenosine 3',5'-bismonophosphate(4-)
Reactome.org link: R-HSA-158468