Reaction: The acetyl group from acetyl-CoA is transferred to the NAT2
- in pathway: Acetylation
N-acetylation occurs in two sequential steps via a ping-pong Bi-Bi mechanism. In the first step, the acetyl group from acetyl-CoA is transferred to a conserved cysteine residue (position 68) in the active site of NAT, with consequent release of coenzyme-A. In the second step, the acetyl group is transferred to the acceptor substrate and the enzyme returns to its initial state.
Reaction - small molecule participants:
CoA-SH [cytosol]
Ac-CoA [cytosol]
Reactome.org reaction link: R-HSA-158832
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Reaction input - small molecules:
acetyl-CoA(4-)
Reaction output - small molecules:
coenzyme A(4-)
Reactome.org link: R-HSA-158832