Reaction: SULT1A1 dimer sulfonates NHABP
- in pathway: Cytosolic sulfonation of small molecules
N-hydroxy-4-aminobiphenyl (NHABP) is a genotoxic metabolite of an industrial carcinogen no longer used in the rubber industry. It can be sulfonated in the liver by cytosolic sulfotransferase 1A1 (SULT1A1) (Yamazoe et al. 1999, Weinshilboum et al. 1997, Strott 2002).
Reaction - small molecule participants:
NHABP-SO4 [cytosol]
PAP [cytosol]
NHABP [cytosol]
PAPS [cytosol]
Reactome.org reaction link: R-HSA-158860
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Reaction input - small molecules:
N-hydroxy-4-aminobiphenyl
3'-phosphonato-5'-adenylyl sulfate(4-)
Reaction output - small molecules:
N-hydroxy-4-aminobiphenyl O-sulfate
adenosine 3',5'-bismonophosphate(4-)
Reactome.org link: R-HSA-158860