Reaction: UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG
- in pathway: Heme degradation
The principal conjugate of bilirubin in bile is bilirubin diglucuronide (BDG). UGT1A4 can transfer glucuronic acid (GlcA) to bilirubin (BIL) and bilirubin monoglucuronide (BMG) to form both the monoglucuronide and the diglucuronide (BDG) conjugates respectively (Ritter et al. 1992).
Reaction - small molecule participants:
BDG [endoplasmic reticulum lumen]
UDP [endoplasmic reticulum lumen]
BMG [endoplasmic reticulum lumen]
UDP-GlcA [endoplasmic reticulum lumen]
BDG [endoplasmic reticulum lumen]
UDP [endoplasmic reticulum lumen]
BMG [endoplasmic reticulum lumen]
UDP-GlcA [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-159179
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Reaction input - small molecules:
mono(glucosyluronic acid)bilirubin
UDP-alpha-D-glucuronate(3-)
mono(glucosyluronic acid)bilirubin
UDP-alpha-D-glucuronate(3-)
Reaction output - small molecules:
bis(beta-glucosyluronate)bilirubin
UDP
bis(beta-glucosyluronate)bilirubin
UDP
Reactome.org link: R-HSA-159179