Reaction: p38 MAPK phosphorylates PPARGC1A
- in pathway: Activation of PPARGC1A (PGC-1alpha) by phosphorylation
As inferred from mouse, p38 MAPK phosphorylates PGC-1alpha (PPARGC1A). Because p38 MAPK is responsive to intracellular calcium, this reaction may couple exercise to mitochondrial biogenesis.
Phosphorylated p38 MAPK is found in the nucleus (Chan et al. 2004, http://www.cellsignal.com/products/4511.html, inferred from mouse in Blanco-Aparicio et al. 1999). p38 MAPK alpha, beta, and gamma (but not delta) are found in skeletal muscle (Jiang et al. 1997). PPARGC1A (PGC-1alpha) is predominantly nuclear (Knutti et al. 2001). As inferred from rat, PPARGC1A may translocate from the cytosol to the nucleus during activation (Wright et al. 2007).
Phosphorylated p38 MAPK is found in the nucleus (Chan et al. 2004, http://www.cellsignal.com/products/4511.html, inferred from mouse in Blanco-Aparicio et al. 1999). p38 MAPK alpha, beta, and gamma (but not delta) are found in skeletal muscle (Jiang et al. 1997). PPARGC1A (PGC-1alpha) is predominantly nuclear (Knutti et al. 2001). As inferred from rat, PPARGC1A may translocate from the cytosol to the nucleus during activation (Wright et al. 2007).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-1592233
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-1592233