Reaction: AMPK phosphorylates PPARGC1A
- in pathway: Activation of PPARGC1A (PGC-1alpha) by phosphorylation
As inferred from mouse, AMPK is activated by AMP and phosphorylates PGC-1alpha (PPARGC1A). It is hypothesized that this reaction connects energy depletion (low ATP, high AMP) to mitochondrial biogenesis (activation of PGC-1alpha).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-1592244
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-1592244