Reaction: SULT1A3,4 dimers sulfate DA to DAOS
- in pathway: Cytosolic sulfonation of small molecules
The catecholamine neurotransmitter dopamine (DA) is predominantly (>95%) conjugated with sulfate (dopamine 3-O-sulfate, DAOS) in human blood circulation. Human SULT1A3 and SULT1A4 are the major sulfotransferases that sulfonate DA (as well as other catecholamines and phenols) (Reiter et al. 1983, Johnson et al. 1980, Thomae et al. 2003, Hildebrandt et al. 2004).
Reaction - small molecule participants:
DAOS [cytosol]
PAP [cytosol]
PAPS [cytosol]
DA [cytosol]
Reactome.org reaction link: R-HSA-159358
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Reaction input - small molecules:
3'-phosphonato-5'-adenylyl sulfate(4-)
dopaminium(1+)
Reaction output - small molecules:
dopamine 3-O-sulfate
adenosine 3',5'-bismonophosphate(4-)
Reactome.org link: R-HSA-159358