Reaction: Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)
- in pathway: Recycling of bile acids and salts
Cholate or chenodeoxycholate, coenzyme A, and ATP react to form their CoA conjugates, AMP, pyrophosphate and water. This reaction is catalyzed by SLC27A5 (BACS) associated with the endoplasmic reticulum membrane, but the substrates and products are cytosolic (Mihalik et al. 2002).
Reaction - small molecule participants:
PPi [cytosol]
H2O [cytosol]
AMP [cytosol]
ATP [cytosol]
CoA-SH [cytosol]
Reactome.org reaction link: R-HSA-159425
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Reaction input - small molecules:
ATP(4-)
coenzyme A(4-)
Reaction output - small molecules:
diphosphate(3-)
water
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-159425