Reaction: Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine
- in pathway: Recycling of bile acids and salts
Cytosolic bile acid-CoA conjugates (choloyl-CoA; chenodeoxycholoyl-CoA) react with the amino acids glycine and taurine, generating the corresponding bile salts and coenzyme A, catalyzed by BAAT (bile acid-CoA:amino acid N-acetyltransferase). In the body, this reaction occurs in hepatocytes and is the means by which bile acids recovered from the intestine are converted to bile salts before being released again into the bile (Kullak-Ublick et al. 2004; Trauner and Boyer 2002).
Reaction - small molecule participants:
CoA-SH [cytosol]
Reactome.org reaction link: R-HSA-159431
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Reaction input - small molecules:
Reaction output - small molecules:
coenzyme A(4-)
Reactome.org link: R-HSA-159431