Reaction: benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate
- in pathway: Conjugation of benzoate with glycine
Benzoate and ATP react with coenzyme A to form benzoyl CoA, AMP, and pyrophosphate (Vessey et al. 1999, 2003). Two human CoA ligases have been characterized that catalyze this reaction efficiently in vitro: acyl-CoA synthetase medium-chain family member 1 (BUCS1) (Fujino et al. 2001) and xenobiotic/medium-chain fatty acid:CoA ligase (Vessey et al. 2003). Their relative contributions to benzoate metabolism in vivo are unknown.
Reaction - small molecule participants:
AMP [mitochondrial matrix]
PPi [mitochondrial matrix]
BEZ-CoA [mitochondrial matrix]
CoA-SH [mitochondrial matrix]
ATP [mitochondrial matrix]
BENZA [mitochondrial matrix]
Reactome.org reaction link: R-HSA-159443
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Reaction input - small molecules:
coenzyme A(4-)
ATP(4-)
benzoic acid
Reaction output - small molecules:
adenosine 5'-monophosphate(2-)
diphosphate(3-)
benzoyl-CoA(4-)
Reactome.org link: R-HSA-159443