Reaction: ACSM2B-like proteins transform ST to ST-CoA
- in pathway: Conjugation of salicylate with glycine
Salicylate (ST) and ATP react with coenzyme A to form salicylate-CoA (ST-CoA), AMP, and pyrophosphate in a reaction catalyzed by xenobiotic/medium-chain fatty acid:CoA ligase (Vessey et al. 2003).
Reaction - small molecule participants:
AMP [mitochondrial matrix]
PPi [mitochondrial matrix]
ST-CoA [mitochondrial matrix]
CoA-SH [mitochondrial matrix]
ATP [mitochondrial matrix]
ST [mitochondrial matrix]
Reactome.org reaction link: R-HSA-159567
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Reaction input - small molecules:
coenzyme A(4-)
ATP(4-)
salicylate
Reaction output - small molecules:
adenosine 5'-monophosphate(2-)
diphosphate(3-)
2-hydroxybenzoyl-CoA
Reactome.org link: R-HSA-159567